Acrylamide-PEG-SCM is a linear heterobifunctional PEG reagent with an Acrylamide (ACA) and an activated NHS ester. The C=C double bond is connected to PEG via an amide bond. It is a useful crosslinking reagent with a PEG spacer. Acrylamide can polymerize with UV light or radical initiator, and SCM is one type of NHS esters, often called succinimidyl carboxyl methyl (SCM) ester. SCM is very reactive with primary amine to form a stable amide bond. Acrylamide-PEG-SCM may be used to introduce an amine reactive functional group in crosslinked PEG hydrogel.

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